Chronic granulomatous disease (CGD) is an inherited disorder of phagocytes that affects their ability to undergo the respiratory burst needed to kill certain types of bacteria and fungi. In addition to persistent tissue granuloma formation, this leads to recurrent potentially deadly bacterial and fungal infections. Early reports in the 1950s described a syndrome comprising recurrent infections, edema, hypergammaglobulinemia, liver disease Please consider citing a recent review and/or whether the definition has developed.

Please make sure this is correct, and be careful to use modern terminology. , and lymphadenopathy. Most cases are detected in boys under 5 years old. Almost all are detected by the age of 16 years We have moved this here as it seems more logical. , and >90% of patients die before the age of 10 years [1]. This diagnosis is usually considered because of a history of unusual, recurrent, or persistent infections. CGD is caused by mutations in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system. The original was unclear. Please check whether this reflects your intended meaning. The identification of this defect has allowed the identification of milder phenotypes. These milder phenotypes may result in milder disease, unusual features, and delayed symptoms, which then delays diagnosis, sometimes even until adulthood [2–3] Please note the citation formatting was inconsistent. We have formatted it in accordance with journal guidelines.